Author(s): El-Halawany AM, El Dine RS, El Sayed NS, Hattori M
Aframomum melegueta is a commonly used African spice. Through a hepatoprotective bioassay-guided isolation, the chloroform fraction of A.melegueta seeds yielded one new diarylheptanoid named 3-(S)-acetyl-1-(4′-hydroxy-3′, 5′-di methoxyphenyl)-7-(3″,4″, 5″-trihydroxyphenyl)heptane (1) and two new hydroxyphenylalkanones, -dehydrogingerdione (2) and -dehydroparadol (3), in addition to six known compounds (4–9). The hepatoprotective effect of A. melegueta methanol extract, sub-fractions and isolated compounds was investigated using carbon tetrachloride (CCl4)-induced liver injury in a rat hepatocytes model. The methanol, chloroform extracts and compounds 1, 5, 8 and 9 of A. melegueta significantly inhibited the elevated serum alanine aminotransferase (ALT), thiobarbituric acid reactive substances (TBARS), tumor necrosis factor (TNFα), interleukin-1beta (Il-1β), caspase3 and 9 and enhanced the reduced liver glutathione (GSH) level caused by CCl4 intoxication. These results indicate that A.melegueta extracts and isolated compounds play a protective role in CCl4 induced acute liver injury which might be due to elevated antioxidative defense potentials, suppressed inflammatory responses and apoptosis of liver tissue.
Author(s): Newman DJ, Cragg GM, Snader KM
Author(s): Newman DJ, Cragg GM
Author(s): Wilson RM, Danishefsky SJ
Author(s): Lahlou M
Author(s): Konning GH, Agyare C, Ennison B
Author(s): Ngwoke KG, Chevallier O, Wirkom VK, Stevenson P, Elliott CT, et al.
Author(s): Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, et al.
Author(s): Shimamura M, Garcia JM, Prough DS, Hellmich HL
Author(s): Hellmich HL, Eidson KA, Capra BA, Garcia JM, Boone DR, et al.
Author(s): Doppenberg EM, Choi SC, Bullock R
Author(s): Xiong Y, Mahmood A, Chopp M