Author(s): Liu G, Anderson C, Scaltreto H, Barbon J, Kensil CR
QS-21 is a natural saponin adjuvant derived from the tree Quillaja saponaria Molina. Previous studies over a limited dose range suggested the acylation is critical to adjuvant activity. In this study, we prepared DS-1 (deacylated QS-21) and RDS-1 (reacylated DS-1 with dodecylamine at a different site than QS-21) to determine the effect on a dose-response curve over a wider range in mice. DS-1 and RDS-1 induced IgG1 responses at higher doses compared to that induced by QS-21. DS-1 was inactive for inducing IgG2a or CTL responses at any doses. RDS-1 showed moderate IgG2a response at 240 microg, but did not show CTL response at any dose evaluated.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12034108
Author(s): Kensil CR, Kammer R
Author(s): Kensil CR, Patel U, Lennick M, Marciani D
Author(s): Kensil CR
Author(s): Garçon N, Van Mechelen M
Author(s): Garçon N, Chomez P, Van Mechelen M
Author(s): Sun HX, Xie Y, Ye YP
Author(s): Ragupathi G, Gardner JR, Livingston PO, Gin DY
Author(s): Lee S, Nguyen MT
Author(s): Warshakoon HJ, Hood JD, Kimbrell MR, Malladi S, Wu WY, et al
Author(s): Dalsgaard K
Author(s): Campbell JB, Peerbaye YA
Author(s): Kenney JS, Hughes BW, Masada MP, Allison AC
Author(s): Song X, Hu S
Author(s): Borja GPC, Correia NNP, Silva VOD, Paraguai SED, Santos WR, et al.
Author(s): Kirk DD, Rempel R, Pinkhasov J, Walmsley AM
Author(s): Hu KF, Lövgren-Bengtsson K, Morein B
Author(s): Morein B, Hu KF, Abusugra I
Author(s): Kersten G, Hirschberg H
Author(s): Aguilar JC, Rodríguez EG
Author(s): Kensil CR, Wu JY, Anderson CA, Wheeler DA, Amsden J
Author(s): Katayama S, Oda K, Ohgitani T, Hirahara T, Shimizu Y
Author(s): Marciani DJ, Kensil CR, Beltz GA, Hung CH, Cronier J, et al.
