Red wine: a source of potent ligands for peroxisome proliferator-activated receptor γ

Author(s): Zoechling A, Liebner F, Jungbauer A


Moderate red wine consumption has been correlated with lower incidences of cardiovascular diseases, inflammation, and metabolic diseases such as type 2 diabetes, obesity, and high blood pressure. We studied binding of ligands from different wines to the peroxisome proliferator-activated receptor γ (PPARγ), a key factor in glucose and lipid metabolism. Ellagic acid and epicatechin gallate (ECG) were identified by gas chromatography and mass spectroscopy in the most active wine fractions. They had an affinity to PPARγ similar to that of the standard pharmaceutical agent rosiglitazone, which is used for the treatment of type 2 diabetes. The IC(50) values of ellagic acid and ECG were 5.7 × 10(-7) M and 5.9 × 10(-7) M, respectively. All of the red wines had affinities for PPARγ equivalent to concentrations of rosiglitazone ranging from 52-521 μM. One hundred milliliters of the tested red wines was equivalent to approximately 1.8-18 mg of rosiglitazone. This volume contained an activity equivalent of at least a quarter of (and up to four times) the daily dose of this potent anti-diabetes drug. The ameliorating effects of red wine on metabolic diseases may be partially explained by the presence of PPARγ ligands.

Similar Articles

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Author(s): Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, et al.

Remodeling of lipid droplets during lipolysis and growth in adipocytes

Author(s): Paar M, Jüngst C, Steiner NA, Magnes C, Sinner F, et al.

Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice

Author(s): Bassaganya-Riera J, DiGuardo M, Climent M, Vives C, Carbo A, et al.

Pomegranate: a fruit that ameliorates metabolic syndrome

Author(s): Medjakovic S, Jungbauer A

Antiobesity effects of wild ginseng (Panax ginseng C

Author(s): Mollah ML, Kim GS, Moon HK, Chung SK, Cheon YP, et al.

Antiobesity effect of oil extract of ginseng

Author(s): Kim HJ, Kang HJ, Seo JY, Lee CH, Kim YS, et al.

Activating effect of momordin, extract of bitter melon (Momordica Charantia L

Author(s): Sasa M, Inoue I, Shinoda Y, Takahashi S, Seo M, et al.

Hypoglycemic effects of crude polysaccharide from Purslane

Author(s): Gong F, Li F, Zhang L, Li J, Zhang Z, et al.

Effects of Portulaca oleracea L

Author(s): El-Sayed M

Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants

Author(s): P S, Zinjarde SS, Bhargava SY, Kumar AR

Cinnamon in glycaemic control: Systematic review and meta analysis

Author(s): Akilen R, Tsiami A, Devendra D, Robinson N

Effect of cinnamon on glucose control and lipid parameters

Author(s): Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI

Cinnamon for diabetes mellitus

Author(s): Leach MJ, Kumar S

Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes

Author(s): Ariotti N, Murphy S, Hamilton NA, Wu L, Green K, et al.

Fat-specific protein 27 regulates storage of triacylglycerol

Author(s): Keller P, Petrie JT, De Rose P, Gerin I, Wright WS, et al.

Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage

Author(s): Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, et al.

Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice

Author(s): Vroegrijk IO, van Diepen JA, van den Berg S, Westbroek I, Keizer H, et al.