Author(s): Hasegawa H, Sung JH, Matsumiya S, Uchiyama M, Inouye Y, et al.
Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh2, and compound K greatly enhanced the cytotoxicity of the anti-cancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU cytotoxicity was observed in P388/ADM cells in the presence of non-toxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 microM quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively. The reversal of DAU resistance in P388/ADM by quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/7480200
Author(s): Middleton E Jr, Kandaswami C, Theoharides TC
Author(s): Mozaffarian D, Rimm EB
Author(s): Calder PC, Yaqoob P
Author(s): Zuchi C, Ambrosio G, Luscher TF, Landmesser U
Author(s): Shukla SK, Gupta S, Ojha SK, Sharma SB
Author(s): Ceylan-Isik AF, Fliethman RM, Wold LE, Ren J
Author(s): Hsiao WL, Liu L
Author(s): Chan E, Tan M, Xin J, Sudarsanam S, Johnson DE
Author(s): Xiang YZ, Shang HC, Gao XM, Zhang BL
Author(s): Berman M, Erman A, Ben-Gal T, Dvir D, Georghiou GP, et al.
Author(s): Weant KA, Smith KM
Author(s): Sander S, Coleman CI, Patel AA, Kluger J, White CM
Author(s): Shibata S, Fujita M, Itokawa H, Tanaka O, Ishii T
Author(s): Lu JM, Yao Q, Chen C
Author(s): Deng J, Lv XT, Wu Q, Huang XN
Author(s): Chan RY, Chen WF, Dong A, Guo D, Wong MS
Author(s): Hasegawa H, Uchiyama M
Author(s): Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, et al.
Author(s): Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T, Taniyama T
Author(s): Fei XF, Wang BX, Tashiro S, Li TJ, Ma JS, et al.
Author(s): Kim HS, Lee EH, Ko SR, Choi KJ, Park JH, et al.
Author(s): Jia WW, Bu X, Philips D, Yan H, Liu G, et al.
Author(s): Xie X, Eberding A, Madera C, Fazli L, Jia W, et al.
Author(s): Wang Z, Zheng Q, Liu K, Li G, Zheng R
Author(s): Zhang J, Zhou F, Wu X, Gu Y, Ai H, et al.
Author(s): Wang H, Zou H, Kong L, Zhang Y, Pang H, et al.
Author(s): Shangguan D, Han H, Zhao R, Zhao Y, Xiong S, et al.
Author(s): Kwon SW, Han SB, Park IH, Kim JM, Park MK, et al.
Author(s): Li L, Zhang JL, Sheng YX, Ye G, Guo HZ, et al.
Author(s): Yu K, Ma Y, Shao Q, Qu H, Cheng Y
Author(s): Li X, Sun J, Wang G, Hao H, Liang Y, et al.
Author(s): Joo KM, Lee JH, Jeon HY, Park CW, Hong DK, et al.
Author(s): Zhang X, Zhang D, Xu J, Gu J, Zhao Y
Author(s): Yang L, Xu SJ, Zeng X, Liu YM, Deng SG, et al.
Author(s): Qian T, Cai Z, Wong RN, Jiang ZH
Author(s): Xie HT, Wang GJ, Sun JG, Tucker I, Zhao XC, et al.
Author(s): Jiang L, Zhao S, Ya L, Li J
Author(s): Li XW, Gui MY, Zheng Y, Jin YR, Zhang HQ
Author(s): Xie HT, Wang GJ, Lv H, Sun RW, Jiang XL, et al.
Author(s): Gu Y, Wang GJ, Sun JG, Jia YW, Wang W, et al.
