Author(s): Mirvish SS
The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in humans are discussed. The principal subjects covered include nitrite-derived alkylating agents that are not NOC, reasons for the wide tissue specificity of carcinogenesis by NOC, the acute toxicity of nitrosamines in humans, mechanisms of in vivo formation of NOC by chemical and bacterial nitrosation in the stomach and via nitric oxide (NO) formation during inflammation, studies on nitrite esters, use of the nitrosoproline test to follow human gastric nitrosation, correlations of nitrate in food and water with in vivo nitrosation and the inhibition of gastric nitrosation by vitamin C and polyphenols. Evidence that specific cancers are caused by NOC is reviewed for cancer of the stomach, esophagus, nasopharynx, urinary bladder in bilharzia and colon. I review the occurrence of nitrosamines in tobacco products, nitrite-cured meat (which might be linked with childhood leukemia and brain cancer) and other foods, and in drugs and industrial situations. Finally, I discuss clues from mutations in ras and p53 genes in human tumors about whether NOC are etiologic agents and draw some general conclusions.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/7600541
Author(s): Yang H, Ding C, Duan Y, Liu J
Author(s): Yang YC
Author(s): Negi JS, Singh P, Rawat B
Author(s): Zhang JS, Wang XM, Dong XH, Yang HY, Li GP
Author(s): Shang J, Zhang GY, Yang CB, Chen Z
Author(s): Brahmachari G, Mondal S, Gangopadhyay A, Gorai D, Mukhopadhyay B, et al.
Author(s): Sun HF, Hu BL, Ding JY, Fan SF
Author(s): Sun HF, Ding JY
Author(s): Louh GN, Lannang AM, Mbazoa CD, Tangmouo JG, Komguem J, et al.
Author(s): Chin YW, Jung HA, Chai H, Keller WJ, Kinghorn AD
Author(s): Fouotsa H, Lannang AM, Mbazoa CD, Rasheed S, Marasini BP, et al.
Author(s): Jantan I, Saputri FC
Author(s): Zhang JS, Wang XM, Gao YT, Li GP
Author(s): Uvarani C, Chandraprakash K, Sankaran M, Ata A, Mohan PS
Author(s): Luo CT, Mao SS, Liu FL, Yang MX, Chen H, et al.
Author(s): Luo CT, Zheng HH, Mao SS, Yang MX, Luo C, et al.
Author(s): Chow CK, Hong CB