Author(s): Wilson RM, Danishefsky SJ
Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.
Referred From: http://pubs.acs.org/doi/abs/10.1021/jo0610053
Author(s): Newman DJ, Cragg GM, Snader KM
Author(s): Newman DJ, Cragg GM
Author(s): Lahlou M
Author(s): El-Halawany AM, El Dine RS, El Sayed NS, Hattori M
Author(s): Konning GH, Agyare C, Ennison B
Author(s): Ngwoke KG, Chevallier O, Wirkom VK, Stevenson P, Elliott CT, et al.
Author(s): Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, et al.
Author(s): Shimamura M, Garcia JM, Prough DS, Hellmich HL
Author(s): Hellmich HL, Eidson KA, Capra BA, Garcia JM, Boone DR, et al.
Author(s): Doppenberg EM, Choi SC, Bullock R
Author(s): Xiong Y, Mahmood A, Chopp M