Author(s): Yamamoto M, Kumagai A, Yamamura Y
Anti-inflammatory action of saikosaponins isolated from the root of Bupleurum falcatum L were examined using female albino rats. The anti-exudative action by granuloma pouch method and the antigranulomatous action by cotton pellet method were demonstrated with i.m. and oral administrations of saikosaponins. The oral administration of saikosaponins in 10 times the dosage of i.m. injection showed almost the same effect. Among saikosaponins isolated from Bupleurum falcatum, saikosaponins a and d, not c, were demonstrated to have anti-inflammatory action. The relationship between structure and action of saikosaponins was discussed. No changes in body weight, adrenal weight, plasma-11-OH-corticosteroid level and hematocrit value were observed.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/1174407
Author(s): Sakurai MH, Matsumoto T, Kiyohara H, Yamada H
Author(s): Yang YY, Tang YZ, Fan CL, Luo HT, Guo PR, et al.
Author(s): Zhu S, Shimokawa S, Shoyama Y, Tanaka H
Author(s): Huang HQ, Zhang X, Xu ZX, Su J, Yan SK, et al.
Author(s): Shyu KG, Tsai SC, Wang BW, Liu YC, Lee CC
Author(s): Zong Z, Fujikawa-Yamamoto K, Ota T, Guan X, Murakami M, et al.
Author(s): Wong VK, Zhou H, Cheung SS, Li T, Liu L
Author(s): Sui C Zhang J, Wei J, Chen S, Li Y, et al.
Author(s): Yen MH, Lin CC, Chang CH, Lin SC
Author(s): Ling RF
Author(s): Bansal N, Blum A, Chawla S
Author(s): Ashour ML, Wink M
