Author(s): Udayama M, Ohkawa M, Yoshida N, Kinjo J, Nohara T
Three new saponins, named palustrosides I, II and III, together with azukisaponins II, V and soyasapogenol B monoglucuronide, were isolated from the aerial parts of Lathylus palustris L. var. pilosus Ledeb. The structures of palustrosides I, II and III were identified as 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucuronopyranosides of soyasapogenol E, abrisapogenol E, and bredemolic acid 28-O-beta-D-glucopyranoside, respectively, by spectroscopic and chemical methods. As part of our studies on hepatoprotective drugs, we also examined the hepatoprotective effects of these saponins towards immunologically induced liver injury in primary cultured rat hepatocytes. The activity of the disaccharide group was greater than that of the trisaccharide group. This information regarding the structure-activity relationships substantiated previously obtained data. Structure-hepatoprotective relationships for the sapogenol moiety suggested that the hydroxyl group at C-30 reduces the hepatoprotective effect. On the other hand, the carbonyl group at C-22 may be equivalent to a hydroxyl group at C-22 in terms of hepatoprotective action. Oleanolic acid-type saponins also exhibited hepatoprotective action.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/9775436
Author(s): Mahato SB, Garai S
Author(s): Lacalla-Dubois M, Wagner H
Author(s): Francis G, Kerem Z, Makkar HP, Becker K
Author(s): Vincken JP, Heng L, de Groot A, Gruppen H
Author(s): Dinda B, Debnath S, Mohanta BC, Harigaya Y
Author(s): Agarwal SK, Rastogi RP
Author(s): Chandel RS, Rastogi RP
Author(s): Mahato SB, Ganguly AN, Sahu NP
Author(s): Mahato SB, Garai S, Chakravarty AK
Author(s): Chakravarty AK, Garai S, Masuda K, Nakane T, Kawahara N
Author(s): Murray AP, Muniain C, Seldes AM, Maier MS
Author(s): Welfender J, Rodriguez S, Hostettmann K
Author(s): Renukappa T, Roos G, Klaiber I, Vogler B, Kraus W
Author(s): Nyberg NT, Baumann H, Kenne L
Author(s): Williams DH, Bradley C, Bojesen G
Author(s): Lattimer RP, Schulten HR
Author(s): Sundqvist B, Roepstorff P, Fohlman J, Hedin A, Håkansson P, et al.
Author(s): Karas M, Hillenkamp F
Author(s): Broberg S, Nord LI, Kenne L
Author(s): Liu J, Yang X, He J, Xia M, Xu L, et al.
Author(s): Zehl M, Pittenauer E, Jirovetz L, Bandhari P, Singh B et al.
Author(s): Germonprez N, Puyvelde LV, Maes L, Tri MV, De Kimpe N
Author(s): Zhang H, Lu Z, Tan GT, Qiu S, Farnsworth NR et al.
Author(s): Zhang XM, Yang DP, Xie ZY, Xue X, Zhu LP, et al.
Author(s): Arslan I
Author(s): Ma L, Yu AH, Sun LL, Gao W, Zhang MM et al.
Author(s): Moniuszko-Szajwaj B, Pecio L, Kowalczyk M, Simonet AM, Macias FA, et al.
Author(s): Xi FM, Li CT, Mi JL, Wu ZJ, Chen WS
Author(s): Lacaille-Dubois MA, Wagner H
Author(s): Li XC, ElSohly HN, Nimrod AC, Clark AM
Author(s): Bills G, Dombrowski A, Morris SA, Hensens O, Liesch, JM et al.
Author(s): Chludil HD, Muniain CC, Seldes AM, Maier MS
Author(s): Huang H, Liao S, Chang F, Kuo Y, Wu Y
Author(s): Abdel-Gawad MM, El-Amin SM, Ohigashi H, Watanabe Y, Takeda N, et al.
Author(s): Jayasinghe ULB, Fujimoto Y, Hostettmann K
Author(s): Cheng G, Zhang Y, Zhang X, Tang H, Cao W et al.
Author(s): Kim YS, Kim JS, Choi SU, Kim JS, Lee HS, et al.
Author(s): Zheng L, Zheng J, Zhao Y, Wang B, Wu L, et al.
Author(s): Xiao K, Yi YH, Wang ZZ, Tang HF, Li YQ, et al.
Author(s): Kuroda M, Mimaki Y, Sashida Y, Kitahara M, Yamazaki M et al.
Author(s): Mimaki Y, Hurade H, Sakuma C, Haraguchi M, Yui S et al.
Author(s): Zou Z, Yi Y , Wu H, Wu J, Liaw C et al.
Author(s): Mimaki Y, Harada H, Sakuma C, Haraguchi M, Yui S, et al.
Author(s): Zhao M, Ma N, Qiu F, Hai WL, Tang HF, et al.
Author(s): Li X, Zhao J, Peng C, Chen Z, Liu Y, et al.
Author(s): Li Q, Deng L, Li W, Koike K
Author(s): Cheng L, Xia TS, Wang YF, Zhou W, Liang XQ, et al.
Author(s): Han L, Fang Y, Li M, Yang H, Huang F
Author(s): Yoshikawa M, Murakami T, Matsuda H, Yamahara J, Murakami N, et al.
Author(s): Yoshikawa M, Murakami T, Matsuda H, Yamahara J, Murakami N, et al.
Author(s): Sakurai T, Nishimura T, Otake N, Xinsheng Y, Abe K, et al.
Author(s): Kako M, Miura T, Nishiyama Y, Ichimaru M, Moriyasu M, et al.
Author(s): Sakurai T, Nishimura T, Otake N, Xinsheng Y, Abe K, et al.
Author(s): Hu X, Wang S, Xu J, Wang DB, Chen Y, et al.
Author(s): Koneri RB, Samaddar S, Ramaiah CT
Author(s): Sinha J, Raay B, Das N, Medda S, Garai S, et al.
Author(s): Sumathy T, Subramanian S, Govindasamy S, Balakrishna K, Veluchamy G
Author(s): Matsuda H, Murakami T, Ninomiya K, Inadzuki M, Yoshikawa M
Author(s): Huang B, Fu HZ, Chen WK, Luo YH, Ma SC
Author(s): Wang Y, Zhang CL, Liu YF, Liang D, Luo H, et al.
Author(s): Pawar RS, Bhutani KK
Author(s): Li S, Zhao J, Liu Y, Chen Z, Xu Q, et al.
Author(s): Qiu M, Kim JH, Lee HK, Min BS
Author(s): Song W, Si L, Ji S, Wang H, Fang XM, et al.
Author(s): Yang XW, Zhao J, Cui YX, Liu XH, Ma CM, et al.
Author(s): Li JP, Liang ZM, Yuan Z
Author(s): Ukiya M, Akihisa T, Yasukawa K, Koike K, Takahashi A, et al.
Author(s): Choo MK, Park EK, Han MJ, Kim DH
Author(s): Bi Y, Ma C, Zhang H, Zhou Z, Yang J, et al.
Author(s): Eisenreich W, Bacher A, Arigoni D, Rohdich F
Author(s): Washida D, Shimomura K, Nakajima Y, Takido M, Kitanaka S
Author(s): Mallol A, Cusidó RM, Palazón J, Bonfill M, Morales C, et al.
Author(s): Sahu NP, Koike K, Jia Z, Achari B, Banerjee S, et al.
Author(s): Toth G, Simon A, Elganal MHA, Soliman SM, Elmunajjed DT, et al.
Author(s): Radwan MM, El-Sebakhy NA, Asaad AM, Toaima SM, Kingston DG
Author(s): Lavaud C, Crublet ML, Pouny I, Litaudon M, Sévenet T
Author(s): Perrone A, Masullo M, Bassarello C, Hamed AI, Belisario MA, et al.
Author(s): Abdel Khalik SM, Miyase T, El-Ashaal HA, Melek FR
Author(s): Tabudravu JN, Jaspars M
Author(s): Hu L, Chen Z, Xie Y
Author(s): Yin F, Hu LH
Author(s): Luo JG, Kong LW
Author(s): Koike K, Jia Z, Nikaido T
Author(s): Kanchanapoom T, Kasai R, Yamasaki K
Author(s): Kitajima M, Hashimoto K, Yokoya M, Takayama H, Sandoval M, et al.
Author(s): Jia Z, Koike K, Kudo M, Li H, Nikaido T
Author(s): Cuéllar MJ, Giner RM, Recio MC, Just MJ, Máñez S, et al.
