Author(s): Kulka M
Benzotrifluoride (BTF, trifluoromethylbenzene, α,α,α-trifluorotoluene, C6H5CF3) and related compounds are introduced as new solvents for traditional organic synthesis and for fluorous synthesis. BTF is more environmentally friendly than many other organic solvents and is available in large quantities. BTF is relatively inert and is suitable for use as a solvent for a wide range of chemistry including ionic, transition-metal catalyzed and thermal reactions. It is especially useful for radical reactions, where it may replace benzene as the current solvent of choice for many common transformations. BTF and related solvents are also crucial components of fluorous synthesis since they can dissolve both standard organic molecules and highly fluorinated molecules. This chapter provides an overview of the reactivity and toxicological properties of BTF and analogs and then summarizes their recent uses as reaction solvents in both traditional organic and new fluorous synthesis.
Referred From: https://www.researchgate.net/publication/226259881_Benzotrifluoride_and_Derivatives_Useful_Solvents_for_Organic_Synthesis_and_Fluorous_Synthesis
Author(s): Mc Vaugh R
Author(s): DahlgrenR, ThorneRF
Author(s): Rojas-RodríguezF, Torres-CórdobaG
Author(s): ShaabanaHAE, El-Ghoraba AH, Shibamoto T
Author(s): Vekiari SA, Protopapadakis EE, Papadopoulou P,Papanicolaou D, Panou C, et al.
Author(s): Blanco Tirado C, Stashenko EE, Combariza MY, Martinez JR
Author(s): Tucker AO, Maciarello MJ, Landrum LR
Author(s): Chen HC, Sheu MJ, Lin LY, Wu CM
Author(s): Chalannavar RK, Venugopala KN, Baijnath H, Odhav B
Author(s): Pichersky E, Gershenzon J
Author(s): Unsicker SB, Kunert G, Gershenzon J
Author(s): Sharma A, Sehrawat SK, Singhrot RS, Tele A
Author(s): Katiyar KP, Camacho Molina J, Matheus R
Author(s): Li Y, Cracker LE, Potter T
Author(s): Maffeia M, Scannerinia S
Author(s): Feijó E,Oliveira R, Costa L
Author(s): Dudai D, Putievsky E, Ravid U, Palevitch D, Halevy AH
Author(s): Zabaras D, Spooner-Hart R, Wyllie S
Author(s): Batista R, de Jesús Silva JúniorA, de OliveiraAB
Author(s): Choi SJ, Kim JK, KimHK, HarrisK,KimCJ, et al.