The pharmacology of curcumin: is it the degradation products? Trends mol Med 18: 138-144

Author(s): Shen L, Ji HF


The natural product curcumin has gained considerable attention in recent years for its multiple pharmacological activities, but more efforts are needed to understand how curcumin can have these pharmacological effects considering its low bioavailability. In addition, it is unclear how curcumin exerts inhibitory effects against numerous enzymes, especially those that cannot accommodate curcumin within recognized binding pockets. By analyzing the similarities between the biological activities of curcumin and its degradation products against diseases such as Alzheimer's disease and cancer, as well as the preferential inhibition of some enzymes by degradation products, it appears that the bioactive degradation products may contribute to the pharmacological effects of curcumin. This possibility should be given full attention when elucidating the pharmacology of this promising natural product for various diseases.

Similar Articles

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

Author(s): Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, et al.

Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria

Author(s): Syu WJ, Shen C, Don MJ, Ou JC, Lee GH, et al.

Stability of curcumin in buffer solutions and characterization of its degradation products

Author(s): Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, et al.

Studies on the stability of turmeric constituents

Author(s): Pfeiffera E, Höhlea S, Solyomb AM, Metzlera M

Simultaneous determination of three curcuminoids in Curcuma longa L

Author(s): Long Y, Zhang W, Wang F, Chen Z

A Simple Isocratic HPLC Method for the Simultaneous Determination of Curcuminoids in Commercial Turmeric Extracts

Author(s): Wichitnithad W, Jongaroonngamsang N, Pummangura S, Rojsitthisak P