The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart

Author(s): Drury AN, Szent-Györgyi A


The purine nucleoside adenosine (Ado) is now recognized as an important physiologic modulator of the cardiovascular system. Its negative chronotropic and dromotropic actions on sinus node (SN) automaticity and atrio-ventricular (AV) nodal conduction, respectively and the vasodilatory action on the coronary vasculature have been known for more than six decades (1). In recent years, numerous other actions of Ado have been described (2) and its role as an endogenous cardioprotective agent has been established (3,4).

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