The role of caspases in cell death and differentiation

Author(s): Oliver L, Vallette FM


The complexity, redundancy and interdependence of the biological systems involved in tumour response to different treatments hamper progress towards developing specific and effective therapies. In addition, the many and even contradictory roles played by certain key proteins can significantly amend our view on tumourigenesis. The role of caspases in the modulation of cell death and differentiation is a prominent example of such a complexity. Here we focus on the role of caspases in apoptotic cell death, mainly in haematological malignancies, tumourigenesis, sepsis, T-cell proliferation and cell differentiation.

Similar Articles

Colorectal cancer screening - methodology

Author(s): Jenkinson F, Steele RJ

Leptadenia pyrotechnica (Forssk

Author(s): El Ghonemy AA

Pregnane glycosides from Leptadenia pyrotechnica

Author(s): Cioffi G, Sanogo R, Vassallo A, Dal Piaz F, Autore G, et al.

Antioxidant, anti-lipoxygenase and cytotoxic activity of Leptadenia pyrotechnica (Forssk

Author(s): Khasawneh MA, Elwy HM, Hamza AA, Fawzi NM, Hassan AH

The p53 network: p53 and its downstream genes

Author(s): Shu KX, Li B, Wu LX

The role of the Bcl-2 protein family in cancer

Author(s): Coultas L, Strasser A

Diterpenes from the leaves of Croton zambesicus

Author(s): Block S, Baccelli C, Tinant B, Van Meervelt L, Rozenberg R, et al.

Biological effects of conjugated linoleic acids in health and disease

Author(s): Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G