The role of vitamin E in atherosclerosis

Author(s): Upston JM, Kritharides L, Stocker R


Epidemiological and biochemical studies infer that oxidative processes, including the oxidation of low-density lipoprotein (LDL), are involved in atherosclerosis. Vitamin E has been the focus of several large supplemental studies of cardiovascular disease, yet its potential to attenuate or even prevent atherosclerosis has not been realised. The scientific rationale for vitamin E supplements protecting against atherosclerosis is based primarily on the oxidation theory of atherosclerosis, the assumption that vitamin E becomes depleted as disease progresses, and the expectation that vitamin E prevents the oxidation of LDL in vivo and atherogenic events linked to such oxidation. However, it is increasingly clear that the balance between vitamin E and other antioxidants may be crucial for in vivo antioxidant protection, that vitamin E is only minimally oxidised and not deficient in atherosclerotic lesions, and that vitamin E is not effective against two-electron oxidants that are increasingly implicated in both early and later stages of the disease. It also remains unclear as to whether oxidation plays a bystander or a casual role in atherosclerosis. This lack of knowledge may explain the ambivalence of vitamin E and other antioxidant supplementation in atherosclerosis.

Similar Articles

Oxidative stress and atherosclerosis

Author(s): Singh U, Jialal I

Oxidative stress in Alzheimer's disease

Author(s): Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G

Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease

Author(s): Guidi I, Galimberti D, Lonati S, Novembrino C, Bamonti F, et al.

Role of quinones in toxicology

Author(s): Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ

Circulating antioxidants in ulcerative colitis and their relationship to disease severity and activity

Author(s): Ramakrishna BS, Varghese R, Jayakumar S, Mathan M, Balasubramanian KA

The plasma membrane redox system in aging

Author(s): Hyun DH, Hernandez JO, Mattson MP, de Cabo R

Free radicals, metals and antioxidants in oxidative stress-induced cancer

Author(s): Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M

Assessment of the Polyphenol Components and In VitroAntioxidant Properties of Syzygiumaromaticum (L

Author(s): Atawodi SE, Atawodi JC, Pfundstein B, Spiegelhalder B, Bartsch H, et al.

(2009b) Polyphenol composition and antioxidant potential of Hibiscus esculentus L

Author(s): Atawodi SE, Atawodi JC, Idakwo GA, Pfundstein B, Haubner R, et al