Author(s): Tasaka AC, Weg R, Calore EE, Sinhorini IL, Dagli ML, et al.
The effect was investigated of administering ground Senna occidentalis seeds to rabbits in different concentrations (1%, 2%, 3% and 4%) in the ration. The experiment lasted 30 days and the toxic effects of the plant were evaluated on the basis of weight gain, histopathological, biochemical and morphometric parameters, as well as histochemistry and electron microscopy. Animals that received the ration containing 4% ground S. occidentalis seeds gained less weight (p < 0.05) and died in the third week. Histopathology revealed that the heart and liver were the main organs affected, with myocardial necrosis and centrolobular degeneration. There was a reduction in cytochrome oxidase activity in the glycogenolytic fibres, together with muscle atrophy, confirmed by the morphometric studies. Electron microscopy of the liver cells revealed dilated mitochondria, with destruction of the internal cristae.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/11305748
Author(s): (2008) Ministry of Agriculture, Animal Industry & Fisheries and Uganda Beareau of statistics, The National Livestock Census Report, Ministry of Agriculture.
Author(s): Nalule AS, Mbaria JM, Olila D, Kimenju JW
Author(s): Nabukenya I, Rubaire-Akiiki C, Olila D, Ikwap K, Höglund J
Author(s): Tabuti JR, Kukunda CB, Waako PJ
Author(s): Olila D, Bukenya-Ziraba R and Kamoga D
Author(s): Ssegawa P, Kasenene JM
Author(s): Githiori JB, Höglund J, Waller PJ
Author(s): Pieroni A, Howard P, Volpato G, Santoro RF
Author(s): Nanyingi MO, Mbaria JM, Lanyasunya AL, Wagate CG, Koros KB, et al.
Author(s): The plant list.
Author(s): Stevenson PC, Kite GC, Lewis GP, Forest F, Nyirenda SP, et al.
Author(s): Dzenda T, Ayo JO, Adelaiye AB, Adaudi AO
Author(s): Iwalokun BA, Efedede BU, Alabi-Sofunde JA, Oduala T, Magbagbeola OA, et al.
Author(s): Alawa CB, Adamu AM, Gefu JO, Ajanusi OJ, Abdu PA, et al.
Author(s): Toyang NJ, Verpoorte R
Author(s): Adedapo AA, Otesile AT, Soetan KO
Author(s): Yadav JP, Arya V, Yadav S, Panghal M, Kumar S, et al.
Author(s): Tona L, Mesia K, Ngimbi NP, Chrimwami B, Okond'ahoka, et al.
Author(s): Verma L, Khatri A, Kaushik B, Patil UK, Pawar RS
Author(s): Dzenda T, Ayo JO, Adelaiye AB, Adaudi AO and Ibrahim DG
Author(s): Ojiako OA, Nwanjo HU
Author(s): Panwar RS, Kumar N
Author(s): Vashishtha VM, John TJ, Kumar A
Author(s): Suliman HB, Wasfi IA, Adam SE
Author(s): Rogers RJ, Gibson J, Reichmann KG
Author(s): Silva MG, Aragão TP, Vasconcelos CF, Ferreira PA, Andrade BA, et al.
Author(s): Hartmann E, Strauss V, Eiben R, Freyberger A, Kaufmann W, et al.
Author(s): Hussain T, Fareed S, Siddiqui HH, Vijaykumar M, Rao CV
Author(s): Amole OO, Izegbu MC, Onakoya JAA, Dada MO
Author(s): Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure
Author(s): Ouedraogo M, Baudoux T, Stévigny C, Nortier J, Colet JM, et al.
Author(s): Sparg SG, Light ME, van Staden J
Author(s): Nalule AS, Karue CN, Katunguka-Rwakishaya E
Author(s): Wasswa P, Olila D
Author(s): Matsumura F
Author(s): Jafri MA, JalisSubhani M, Javed K, Singh S