Author(s): Shuaibu MN, Wuyep PT, Yanagi T, Hirayama K, Ichinose A, et al.
The antitrypanosomal activity of methanolic extracts of Anogeissus leiocarpus and Terminalia avicennoides were evaluated in vitro against four strains of Trypanosoma species with minimum inhibitory concentration (MIC) value range of 12.5-50 mg/ml. Successive fractionations of the two plant extracts in water, butanol and ethyl acetate gave a range of activity (MIC, 20 to > or =50 microg/ml). Activity-guided and chromatographic analysis of butanolic fractions on Sephadex LH-20 column followed by high-performance liquid chromatography, nuclear magnetic resonance analysis and both ultraviolet and thin layer chromatography revealed hydrolysable tannins with a range of activity (MIC, 7.5-27.5 microg/ml or 14-91 microM). Effect of the compounds on fibroblasts did not reveal serious toxicity at moderate concentration but is concentration dependent.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18066599
Author(s): Chanie M, Adula D, Bogale B
Author(s): Albadrani BA
Author(s): Chitanga S, Marcotty T, Namangala B, Van den Bossche P, Van Den Abbeele J, et al.
Author(s): Hoet S, Opperdoes F, Brun R, Quetin-Leclercq J
Author(s): Samson W
Author(s): Wurochekke AU, Nok AJ
Author(s): Ibrahim H, Ogbadoyi E, Adamu K, Bello M, Yemisi I
Author(s): Pascaline J, Charles M, Lukhoba C, George O
Author(s): Runyoro DK, Ngassapa OD, Matee MI, Joseph CC, Moshi MJ