18 fluoro deoxy glucose positron emission tomography (18 FDG-PET) visualizes follicular lymphoma irrespective of grading

Author(s): Wohrer S, Jaeger U, Kletter K, Becherer A, Hauswirth A, et al.


Background: 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) has become a routine measure for staging and follow-up of patients with aggressive lymphoma. By contrast, its usefulness to visualize indolent lymphomas characterized by a lower cellular turnover has not clearly been defined. We have investigated accuracy and clinical usefulness of 18F-FDG-PET in patients with follicular lymphoma (FL).

Patients and methods: A total of 64 patients with FL WHO grade I – III (48, 5, and 11 patients) were imaged at our institution to assess the value of 18F-FDG-PET for imaging of FL of different gradings. A total of 115 scans (48 before therapy and 67 for response assessment after treatment) were performed, and findings were compared to conventional staging including CT-scan of thorax and abdomen, sonography of lymph nodes and bone marrow biopsy.

Results: Overall, 18F-FDG-PET had a sensitivity of 98%, a specificity of 94%, a positive predictive value of 95% and a negative predictive value of 98%. These results were significantly more accurate (P = 0.023) than the conventional radiology studies. There was no significant difference (P = 0.093) in the accuracy between patients with indolent (WHO grade I and II) versus aggressive FL (WHO grade III).

Conclusion: 18F-FDG-PET scan is a reliable method for staging and follow up of patients with nodal FL irrespective of tumor grading.

Similar Articles

Revision of the World Health Organization classification of lymphoid neoplasms

Author(s): Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, et al.

US lymphoid malignancy statistics by World Health Organization Subtypes

Author(s): Teras LR, DeSantis EC, Cerhan JR, Morton LM, Flowers CR, et al.

Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immune histo-chemical profile

Author(s): Horn H, Schmelter C, Leich E, Salaverria I, Katzenberger T, et al.

Follicular Lymphoma International Prognostic Index 2: A new prognostic index for Follicular Lymphoma Prognostic Factor Project

Author(s): Federico M, Bellei M, Marcheselli L, Luminari S, Lopez-Guillermo A, et al.

Long term remission of patients with follicular lymphoma grade 3 treated with R CHOP

Author(s): Strati P, Fowler N, Pina-Oviedo S, Medeiros LJ, Overman MJ, et al.