Author(s): Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, et al.
A physiological pharmacokinetic model was developed to describe the disposition of lycopene, delivered as a tomato beverage formulation in five graded doses (10, 30, 60, 90, or 120 mg), for a phase I study in healthy male subjects (five per dose). Blood was collected before dose administration (0 h) and at scheduled intervals until 672 h. Serum concentrations of carotenoids and vitamins were measured by high performance liquid chromatography analysis. The model was comprised of seven compartments: gastrointestinal tract, enterocytes, chylomicrons, plasma lipoproteins, fast-turnover liver, slow-turnover tissues, and a delay compartment before the enterocytes. As predicted, the percent absorption at the 10 mg dose (33.9 +/- 8.1%) was significantly greater than at the higher doses; however, the amount of lycopene absorbed (mg) was not statistically different (mean: 4.69 +/- 0.55 mg) between doses, suggesting a possible saturation of absorptive mechanisms. The slow-turnover tissue compartment served as a slow-depleting reservoir for lycopene, and the liver represented the fast-turnover pool. Independent of dose, 80% of the subjects absorbed less than 6 mg of lycopene. This may have important implications for planning clinical trials with pharmacological doses of lycopene in cancer control and prevention if absorption saturation occurs at levels that are already being consumed in the population.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12867539
Author(s): Giovannucci E
Author(s): Giovannucci E
Author(s): Le Marchand L,Hankin JH, Kolonel LN, Wilkens LR
Author(s): Stacewicz-Sapuntzakis M, Bowen PE
Author(s): Mohanty NK,Saxena S, Singh UP, Goyal NK, Arora RP
Author(s): Van Poppel H,Tombal B
Author(s): Madersbacher S, Berger I, Ponholzer A, Marszalek M
Author(s): Azimi H
Author(s): Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, et al.
Author(s): Obermüller-Jevic UC,Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, et al.
Author(s): Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, et al.
Author(s): Schwarz S,Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, et al.
Author(s): Dewell A, Weidner G, Sumner MD, Chi CS, Ornish D
Author(s): Park E,Stacewicz-Sapuntzakis M, Sharifi R, Wu Z, Freeman VL, et al.
Author(s): Parsons JK, Newman VA, Mohler JL, Pierce JP, Flatt S, et al.
Author(s): Carmody JF,Olendzki BC, Merriam PA, Liu Q, Qiao Y, et al.
Author(s): vanBreemen RB,Sharifi R, Viana M, Pajkovic N, Zhu D, et al.
Author(s): Barber NJ, Barber J
Author(s): Hadley CW, Miller EC, Schwartz SJ, Clinton SK
Author(s): Richelle M,Bortlik K, Liardet S, Hager C, Lambelet P, et al.
Author(s): Burri BJ, Chapman MH, Neidlinger TR, Seo JS, Ishida BK
Author(s): Canene-Adams K,Lindshield BL, Wang S, Jeffery EH, Clinton SK, et al.
Author(s): Limpens J,Schröder FH, de Ridder CM, Bolder CA, Wildhagen MF, et al.
Author(s): Yang CM
Author(s): Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, et al.
Author(s): Venkateswaran V,Fleshner NE, Sugar LM, Klotz LH
Author(s): Mucci LA,Tamimi R, Lagiou P, Trichopoulou A, Benetou V, et al.
Author(s): Liu X
Author(s): Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, et al.
Author(s): Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, et al.
Author(s): Talvas J,Caris-Veyrat C, Guy L, Rambeau M, Lyan B, et al.
Author(s): Qiu X, Yuan Y, Vaishnav A, Tessel MA, Nonn L, et al.
Author(s): SoaresNda C,Teodoro AJ, Oliveira FL, Santos CA, Takiya CM, et al.
Author(s): Teodoro AJ, Oliveira FL, Martins NB, Maia Gde A, Martucci RB, et al.
Author(s): Oborna I
Author(s): Kirsh VA,Mayne ST, Peters U, Chatterjee N, Leitzmann MF, et al.
Author(s): Peters U
Author(s): Kristal AR, Till C, Platz EA, Song X, King IB, et al.
Author(s): Ilic D, Forbes KM, Hassed C
Author(s): Bunker CH, McDonald AC, Evans RW, de la Rosa N, Boumosleh JM, et al.
Author(s): Schröder FH,Roobol MJ, Boevé ER, de Mutsert R, Zuijdgeest-van Leeuwen SD, et al.
Author(s): Barber NJ
Author(s): Edinger MS, Koff WJ
Author(s): Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, et al.
Author(s): Morgia G, Russo GI, Voce S, Palmieri F, Gentile M, et al.
Author(s): Morgia G
Author(s): Morgia G,Mucciardi G, Galì A, Madonia M, Marchese F, et al.
Author(s): Blume-Peytavi U