A very-low-fat vegan diet increases intake of protective dietary factors and decreases intake of pathogenic dietary factors

Author(s): Dewell A, Weidner G, Sumner MD, Chi CS, Ornish D

Abstract

There is increasing evidence that dietary factors in plant-based diets are important in the prevention of chronic disease. This study examined protective (eg, antioxidant vitamins, carotenoids, and fiber) and pathogenic (eg, saturated fatty acids and cholesterol) dietary factors in a very-low-fat vegan diet. Ninety-three early-stage prostate cancer patients participated in a randomized controlled trial and were assigned to a very-low-fat (10% fat) vegan diet supplemented with soy protein and lifestyle changes or to usual care. Three-day food records were collected at baseline (n=42 intervention, n=43 control) and after 1 year (n=37 in each group). Analyses of changes in dietary intake of macronutrients, vitamins, minerals, carotenoids, and isoflavones from baseline to 1 year showed significantly increased intake of most protective dietary factors (eg, fiber increased from a mean of 31 to 59 g/day, lycopene increased from 8,693 to 34,464 mug/day) and significantly decreased intake of most pathogenic dietary factors (eg, saturated fatty acids decreased from 20 to 5 g/day, cholesterol decreased from 200 to 10 mg/day) in the intervention group compared to controls. These results suggest that a very-low-fat vegan diet can be useful in increasing intake of protective nutrients and phytochemicals and minimizing intake of dietary factors implicated in several chronic diseases.

Similar Articles

Role of lycopene and tomato products in prostate health

Author(s): Stacewicz-Sapuntzakis M, Bowen PE

Plant extracts: sense or nonsense?CurrOpinUrol 18: 16-20

Author(s): Madersbacher S, Berger I, Ponholzer A, Marszalek M

Lycopene inhibits the growth of normal human prostate epithelial cells in vitro

Author(s): Obermüller-Jevic UC,Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, et al.

Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate

Author(s): Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, et al.

Lycopene inhibits disease progression in patients with benign prostate hyperplasia

Author(s): Schwarz S,Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, et al.

Diet adherence dynamics and physiological responses to a tomato product whole-food intervention in African-American men

Author(s): Park E,Stacewicz-Sapuntzakis M, Sharifi R, Wu Z, Freeman VL, et al.

Lycopene and prostate cancer

Author(s): Barber NJ, Barber J

Tomatoes, lycopene, and prostate cancer: progress and promise

Author(s): Hadley CW, Miller EC, Schwartz SJ, Clinton SK

A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste

Author(s): Richelle M,Bortlik K, Liardet S, Hager C, Lambelet P, et al.

A physiological pharmacokinetic model describing the disposition of lycopene in healthy men

Author(s): Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, et al.

Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas

Author(s): Canene-Adams K,Lindshield BL, Wang S, Jeffery EH, Clinton SK, et al.

Combined lycopene and vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice

Author(s): Limpens J,Schröder FH, de Ridder CM, Bolder CA, Wildhagen MF, et al.

Chemoprevention of prostate cancer with lycopene in the TRAMP model

Author(s): Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, et al.

Antioxidants block prostate cancer in lady transgenic mice

Author(s): Venkateswaran V,Fleshner NE, Sugar LM, Klotz LH

Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer

Author(s): Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, et al.

Lycopene effects on rat normal prostate and prostate tumor tissue

Author(s): Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, et al.

Effects of lycopene on protein expression in human primary prostatic epithelial cells

Author(s): Qiu X, Yuan Y, Vaishnav A, Tessel MA, Nonn L, et al.

Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines

Author(s): Teodoro AJ, Oliveira FL, Martins NB, Maia Gde A, Martucci RB, et al.

A prospective study of lycopene and tomato product intake and risk of prostate cancer

Author(s): Kirsh VA,Mayne ST, Peters U, Chatterjee N, Leitzmann MF, et al.

Lycopene for the prevention of prostate cancer

Author(s): Ilic D, Forbes KM, Hassed C

A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk

Author(s): Bunker CH, McDonald AC, Evans RW, de la Rosa N, Boumosleh JM, et al.

Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis

Author(s): Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, et al.

Serenoarepens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH

Author(s): Morgia G, Russo GI, Voce S, Palmieri F, Gentile M, et al.