Author(s): Lipshultz SE, Scully RE, Lipsitz SR, Sallan SE, Silverman LB, et al.
Doxorubicin chemotherapy is associated with cardiomyopathy. Dexrazoxane reduces cardiac damage during treatment with doxorubicin in children with acute lymphoblastic leukaemia (ALL). We aimed to establish the long-term effect of dexrazoxane on the subclinical state of cardiac health in survivors of childhood high-risk ALL 5 years after completion of doxorubicin treatment.Methods
Between January, 1996, and September, 2000, children with high-risk ALL were enrolled from nine centres in the USA, Canada, and Puerto Rico. Patients were assigned by block randomisation to receive ten doses of 30 mg/m2 doxorubicin alone or the same dose of doxorubicin preceded by 300 mg/m2 dexrazoxane. Treatment assignment was obtained through a telephone call to a centralised registrar to conceal allocation. Investigators were masked to treatment assignment but treating physicians and patients were not; however, investigators, physicians, and patients were masked to study serum cardiac troponin-T concentrations and echocardiographic measurements. The primary endpoints were late left ventricular structure and function abnormalities as assessed by echocardiography; analyses were done including all patients with data available after treatment completion. This trial has been completed and is registered with ClinicalTrials.gov, number NCT00165087.
Author(s): Long ZJ, Hu Y, Li XD, He Y, Xiao RZ, et al.
Author(s): Lipshultz SE, Sambatakos P, Maguire M, Karnik R, Ross SW, et al.
Author(s): Suzumiya J, Ohshima K, Tamura K, Karube K, Uike N, et al.
Author(s): Dalen VEC, Raphael MF, Caron HN, Kremer LC
Author(s): Swain SM, Whaley FS, Ewer MS
Author(s): Kobayashi S, Volden P, Timm D, Mao K, Xu X, et al.
Author(s): Krischer JP, Epstein S, Cuthbertson DD, Goorin AM, Epstein ML, et al.
Author(s): Lipshultz SE, Lipsitz SR, Mone SM, Goorin AM, Sallan SE, et al.
Author(s): Cario G, Rhein P, Mitlohner R, Zimmermann M, Bandapalli OR, et al.
Author(s): Aiken MJ, Suhag V, Garcia CA, Acio E, Moreau S, et al.
Author(s): Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE
Author(s): Yeh ET, Bickford CL
Author(s): Lebrecht D, Setzer B, Ketelsen UP, Haberstroh J, Walker UA
Author(s): Vandecruys E, Mondelaers V, De Wolf D, Benoit Y, Suys B
Author(s): Barge-Caballero E, Segovia-Cubero J, Almenar-Bonet L, Gonzalez-Vilchez F, Villa-Arranz A, et al.
Author(s): Schweiger M, Dave H, Lemme F, Cavigelli-Brunner A, Romanchenko O, et al.
Author(s): Kurihara C, Nishimura T, Nawata K, Kinoshita O, Hisagi M, et al.
Author(s): Lipshultz SE, Franco VI, Cochran TR
Author(s): Orgel E, Zung L, Ji L, Finklestein J, Feusner J, et al.
Author(s): Lipshultz SE, Lipsitz SR, Sallan SE, Dalton VM, Mone SM, et al.
Author(s): Palazzuoli A, Gallotta M, Quatrini I, Nuti R
Author(s): Lipshultz SE, Miller TL, Scully RE, Lipsitz SR, Rifai N, et al.
Author(s): Armenian SH, Hudson MM, Mulder RL, Chen MH, Constine LS, et al.
Author(s): Harake D, Franco VI, Henkel JM, Miller TL, Lipshultz SE
Author(s): Feuerstein GZ, Ruffolo RR
Author(s): Arozal W, Sari FR, Watanabe K, Arumugam S, Veeraveedu PT, et al.
Author(s): Goldberg JM, Scully RE, Sallan SE, Lipshultz SE
Author(s): Thompson PA, Rosner GL, Matthay KK, Moore TB, Bomgaars LR, et al.