B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression

Author(s): Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, et al.


Purpose: B7-H1/PD-L1 (B7-H1) and B7-DC/PD-L2 (B7-DC) are ligands for the receptor PD-1, which is known to negatively regulate T-cell activation. In the present study, we investigated the expression of B7-H1 and B7-DC in tumor specimens of non-small cell lung cancer and their relationships with clinicopathological variables and postoperative survival. Furthermore, we examined the correlation between B7-H1 expression on tumor cells and the number of tumor-infiltrating lymphocytes (TILs) or PD-1 expression on TILs.

Experimental Design: The expression of B7-H1 and B7-DC in 52 surgically resected specimens of non-small cell lung cancer was evaluated immunohistochemically.

Similar Articles

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer

Author(s): Brahmer J, Tykodi S, Chow L, Hwu WJ, Topalian SL, et al.

Nivolumab versus Docetaxel in advanced squamous-cell non-small-cell lung cancer

Author(s): Brahmer J, Reckamp KL, Baas P, Crinò L, Wilfried EE, et al.

Immunotherapy in the treatment of non-small cell lung cancer

Author(s): Sundar R, Soong R, Cho B, Brahmer J, Soo R

When progressive disease does not mean treatment failure: Reconsidering the criteria for progression

Author(s): Oxnard G, Morris M, Hodi F, Baker LH, Kris MG, et al.