Breast cancer and sarcoidosis: Case series and review of the literature

Author(s): Chen J, Carter R 3rd, Maoz D, Tobar A, Sharon E, et al.


Background: Sarcoidosis is a chronic inflammatory disease of unknown etiology, which can involve different organs and systems. Accordingly, sarcoidosis can mimic breast cancer, making the differential diagnosis very difficult. Case Report: 5 patients with a diagnosis of both sarcoidosis and breast cancer followed by the Rabin Medical Center between January 1993 and June 2012 were enrolled in this study. Additionally, a comprehensive literature review which identified 104 patients diagnosed with breast cancer and sarcoidosis was carried out. In both populations reviewed, the average age at diagnosis of sarcoidosis and breast cancer was 57 years. Among the 66 patients with both sarcoidosis and breast cancer, sarcoidosis preceded breast cancer in 31 cases, followed it in 23 cases, and appeared concurrently in 10 cases. Conclusion: Based on our clinical cases and literature review, a histological study is recommended over imaging if sarcoidosis or breast cancer may be present. Furthermore, breast cancer is rarely associated with sarcoidosis or sarcoidosis-like reaction.

Similar Articles


Author(s): Iannuzzi MC, Rybicki BA, Teirstein AS

Pulmonary and mediastinal “sarcoidosis” following surgical resection of cancer

Author(s): Parra ER, Canzian M, Ab’Saber AM, Coelho RS, Rodrigues FG, et al.

Circulating CA 15-3 levels in the postsurgical follow-up of breast cancer patients and in non-malignant diseases

Author(s): Colomer R, Ruibal A, Genollá J, Rubio D, del Campo JM, et al.


Author(s): Newman LS, Rose CS, Maier LA

Sarcoidosis following chemotherapy for Hodgkin's disease

Author(s): Merchant TE, Filippat DA, Yahalom J

18F-FDG PET/CT in sarcoidosis management: review and report of 20 cases

Author(s): Braun JJ, Kessler R, Constantinesco A, Imperiale A