Author(s): Kusakabe T, Maeda M, Hoshino H, Sugino T, Watanabe K, et al.
Animal fatty acid synthase (FAS) is a homodimer protein which synthesizes long-chain fatty acids and is rich in liver, brain, breast, and lung. However, the precise cellular localization of FAS in human tissues has not been elucidated. Immunohistochemistry with a new antibody to human FAS revealed that in adult human tissues FAS is distributed mainly in cells with high lipid metabolism (adipocytes, corpus luteum, hepatocytes, sebaceous glands, and Type II alveolar cells), in hormone-sensitive cells (anterior pituitary, apocrine gland, breast, endometrium, prostate, seminal vesicle, and adrenal cortex), and in a subset of epithelial cells of duodenum and stomach, colon absorptive cells, cerebral neurons, basket cells of cerebellum, decidua, uroepithelium, and epidymis. In fetal cells at 20 weeks of gestation, FAS was mainly present in proliferative epithelial cells of the digestive and respiratory systems, proximal renal tubules, adrenocortical cells, and mesenchymal and hematolymphoid cells. Staining was significant in nonproliferating cells, as observed in adult, and in sympathetic ganglion cells, Leidig cells of testis, and Langhans cells of chorionic villi. FAS is maintained in hormone-sensitive cells and/or cells active in lipid metabolism in the adult and is expressed in proliferating cells in the fetus, suggesting active fatty acid synthesis for energy utilization or membrane lipids.
Referred From: https://jhc.sagepub.com/content/48/5/613.full
Author(s): Sul HS, Wang D
Author(s): Kuhajda FP
Author(s): Liu H, Liu JY, Wu X, Zhang JT
Author(s): Mashima T, Seimiya H, Tsuruo T
Author(s): Maekawa H, Ito T, Orita H, Sato K, Wada R
Author(s): Maekawa H, Ito T, Kushida T, Orita H, Sakurada M, et al.
Author(s): Ghouri YA, Mian I, Blechacz B
Author(s): Bergguist A, von Seth E
Author(s): Zhang JW, Chu YM, Lan ZM, Tang XL, Chen YT, et al.
Author(s): Kiriyama M, Ebata T, Aoba T, Kaneoka Y, Arai T, et al.
Author(s): Sakata J, Wakai T, Matsuda Y, Ohashi T, Hirose Y, et al.
Author(s): Kim HJ, Kim CY, Hur YH, Koh YS, Kim JC, et al.
Author(s): Kwon HJ, Kim SG, Chun JM, Lee WK, Hwang YJ
Author(s): Wang J, Wang X, Xie S, Yan Z, Li Z, et al.
Author(s): Miyamoto M, Ojima h, Iwasaki M, Shimizu H, Kokubu A, et al.
Author(s): Zheng J, Zhu YM
Author(s): Chang YT, Chang MC, Huang KW, Tung CC, Hsu C, et al.
Author(s): Pattanathien P, Khuntikeo N, Promthet S, Kamsa-Ard S
Author(s): Lad N, Kooby DA
Author(s): Yang H, Zhou J, Wei X, Wang F, Zhao H, et al.
Author(s): Im JH, Seong J, Lee IJ, Park JS, Yoon DS, et al.
Author(s): Hoehn RS, Wima K, Ertel AE, Meier A, Ahmad SA, et al.
Author(s): Coleman DT, Bigelow R, Cardelli JA