Author(s): Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, et al.
Epidemiological evidence links consumption of lycopene, the red carotenoid of tomato, to reduced prostate cancer risk. We investigated the effect of lycopene in normal prostate tissue to gain insight into the mechanisms, by which lycopene can contribute to primary prostate cancer prevention. We supplemented young rats with 200 ppm lycopene for up to 8 wk, measured the uptake into individual prostate lobes, and analyzed lycopene-induced gene regulations in dorsal and lateral lobes after 8 wk of supplementation. Lycopene accumulated in all four prostate lobes over time, with all-trans lycopene being the predominant isoform. The lateral lobe showed a significantly higher total lycopene content than the other prostate lobes. Transcriptomics analysis revealed that lycopene treatment mildly but significantly reduced gene expression of androgen-metabolizing enzymes and androgen targets. Moreover, local expression of IGF-I was decreased in the lateral lobe. Lycopene also consistently reduced transcript levels of proinflammatory cytokines, immunoglobulins, and immunoglobulin receptors in the lateral lobe. This indicates that lycopene reduced inflammatory signals in the lateral prostate lobe. In summary, we show for the first time that lycopene reduced local prostatic androgen signaling, IGF-I expression, and basal inflammatory signals in normal prostate tissue. All of these mechanisms can contribute to the epidemiologically observed prostate cancer risk reduction by lycopene.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15545302
Author(s): Giovannucci E
Author(s): Giovannucci E
Author(s): Le Marchand L,Hankin JH, Kolonel LN, Wilkens LR
Author(s): Stacewicz-Sapuntzakis M, Bowen PE
Author(s): Mohanty NK,Saxena S, Singh UP, Goyal NK, Arora RP
Author(s): Van Poppel H,Tombal B
Author(s): Madersbacher S, Berger I, Ponholzer A, Marszalek M
Author(s): Azimi H
Author(s): Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, et al.
Author(s): Obermüller-Jevic UC,Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, et al.
Author(s): Schwarz S,Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, et al.
Author(s): Dewell A, Weidner G, Sumner MD, Chi CS, Ornish D
Author(s): Park E,Stacewicz-Sapuntzakis M, Sharifi R, Wu Z, Freeman VL, et al.
Author(s): Parsons JK, Newman VA, Mohler JL, Pierce JP, Flatt S, et al.
Author(s): Carmody JF,Olendzki BC, Merriam PA, Liu Q, Qiao Y, et al.
Author(s): vanBreemen RB,Sharifi R, Viana M, Pajkovic N, Zhu D, et al.
Author(s): Barber NJ, Barber J
Author(s): Hadley CW, Miller EC, Schwartz SJ, Clinton SK
Author(s): Richelle M,Bortlik K, Liardet S, Hager C, Lambelet P, et al.
Author(s): Burri BJ, Chapman MH, Neidlinger TR, Seo JS, Ishida BK
Author(s): Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, et al.
Author(s): Canene-Adams K,Lindshield BL, Wang S, Jeffery EH, Clinton SK, et al.
Author(s): Limpens J,Schröder FH, de Ridder CM, Bolder CA, Wildhagen MF, et al.
Author(s): Yang CM
Author(s): Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, et al.
Author(s): Venkateswaran V,Fleshner NE, Sugar LM, Klotz LH
Author(s): Mucci LA,Tamimi R, Lagiou P, Trichopoulou A, Benetou V, et al.
Author(s): Liu X
Author(s): Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, et al.
Author(s): Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, et al.
Author(s): Talvas J,Caris-Veyrat C, Guy L, Rambeau M, Lyan B, et al.
Author(s): Qiu X, Yuan Y, Vaishnav A, Tessel MA, Nonn L, et al.
Author(s): SoaresNda C,Teodoro AJ, Oliveira FL, Santos CA, Takiya CM, et al.
Author(s): Teodoro AJ, Oliveira FL, Martins NB, Maia Gde A, Martucci RB, et al.
Author(s): Oborna I
Author(s): Kirsh VA,Mayne ST, Peters U, Chatterjee N, Leitzmann MF, et al.
Author(s): Peters U
Author(s): Kristal AR, Till C, Platz EA, Song X, King IB, et al.
Author(s): Ilic D, Forbes KM, Hassed C
Author(s): Bunker CH, McDonald AC, Evans RW, de la Rosa N, Boumosleh JM, et al.
Author(s): Schröder FH,Roobol MJ, Boevé ER, de Mutsert R, Zuijdgeest-van Leeuwen SD, et al.
Author(s): Barber NJ
Author(s): Edinger MS, Koff WJ
Author(s): Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, et al.
Author(s): Morgia G, Russo GI, Voce S, Palmieri F, Gentile M, et al.
Author(s): Morgia G
Author(s): Morgia G,Mucciardi G, Galì A, Madonia M, Marchese F, et al.
Author(s): Blume-Peytavi U