Author(s): Bielack S, Carrle D, Casali PG
Osteosarcoma is the most frequent primary cancer of bone (incidence: 0.2–3/100 000/year). The incidence is higher in adolescents (0.8–11/100 000/year at age 15–19), where it accounts for >10% of all solid cancers. The male:female ratio is ∼1.4. It usually arises in the metaphysis of a long extremity bone, most commonly around the knee. Involvement of the axial skeleton or craniofacial bones is observed primarily in adults.
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