P53 status and its prognostic role in extrahepatic bile duct cancer: a meta-analysis of published studies

The dysfunction of p53 is the most common genetic alteration in human cancer. A variety of studies have investigated the clinicopathologic correlation of p53 and its impact on patient survival in different types of cancer. For extrahepatic bile duct cancer (EBDC), however, the results were limited and conflicting. In this study, we performed an investigation to confirm whether there was a correlation between p53 status and some routine parameters. To further observe the impact of p53 on the survival of EBDC patients, a meta-analysis based on published studies was conducted. Candidate studies were searched from PubMed, EMBASE, and ISI Web of Science. Our results demonstrated that there were significant correlations between p53 expression and some clinicopathological parameters. Furthermore, the pooled results of the meta-analysis showed that the combined hazard ratio (HR) estimate for overall survival (OS) was 1.53 (95% CI, 1.10–2.14) and 1.23 (95% CI, 0.93–1.75) in univariate and multivariate analysis, respectively. In conclusion, the high level of p53 appears to be an effective prognostic factor to OS of EBDC patients. However, some limitations unavoidable in this meta-analysis and problems of previous p53 studies in EBDC mean that further studies are necessary before significant conclusions can be made.

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Acknowledgments

This work was supported by grants from the Foundation of Shandong Natural Science (No. 2007ZRC03088), the Foundation of Shandong Educational Committee (No. G08LG53), the Scientific Research Foundation of Science and Technology Bureau of Yantai (No. 2008142-13) and the Scientific Research Starting Foundation of Binzhou Medical College (No. BY2006KYQD13). We thank Dr. Wenbin Wang for his critical reading of our manuscript. The authors declare that there is no conflict of interest that would prejudice the impartiality of this work.

Author informationAuthors and Affiliations

Department of Biotechnology, Binzhou Medical College, 264003, Yantai, Shandong Province, People’s Republic of China

Juan Wang

Department of Hepatobiliary Surgery, Yuhuangding Hospital, 264000, Yantai, Shandong Province, People’s Republic of China

Xuefeng Wang

Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People’s Republic of China

Shuyang Xie, Zunling Li, Youjie Li & Fei Jiao

Shanghai Institute of Medical Genetics, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 200040, Shanghai, People’s Republic of China

Zhonghai Yan

Department of Breast Surgery, Shandong Tumor Hospital, 250117, Ji’nan, Shandong Province, People’s Republic of China

Lei Wang

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Correspondence to Fei Jiao.

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Xuefeng Wang and Fei Jiao contributed equally to this work.

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Wang, J., Wang, X., Xie, S. et al. p53 Status and Its Prognostic Role in Extrahepatic Bile Duct Cancer: A Meta-Analysis of Published Studies. Dig Dis Sci 56, 655–662 (2011). https://doi.org/10.1007/s10620-010-1352-9

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Received: 26 November 2009

Accepted: 12 July 2010

Published: 29 July 2010

Issue Date: March 2011

DOI: https://doi.org/10.1007/s10620-010-1352-9