Primary intrahepatic small-cell carcinoma arising from combined hepatocellular and cholangiocarcinomas

Author(s): Khaw YL, Nolan N, Heaslip I, McCormick PA, Sheaha K

Abstract

We report a small-cell carcinoma (SmCC) arising from combined hepatocellular (HCC) and cholangiocarcinomas (CC). Combined HCC and CC comprise less than 1% of liver carcinomas,1 and only 13 cases of primary hepatic SmCC have been reported to date. To our knowledge, ours is the first described case of SmCC arising from combined hepatic carcinoma. In addition, synchronous intrahepatic CC was present in the same liver. We discuss the diagnostic and therapeutic challenges of SmCC as well as the tumorigenesis of the tumor components.

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