Author(s): Maeshima AM, Hirokazu T, Junko N, Ken-ichi M, Suguru F, et al.
This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular lymphoma histologic grade in 255 follicular lymphoma patients who were treated with rituximab-containing therapy. The complete response, overall response, 6-year progression-free survival, and 6-year overall survival rates were 83%, 96%, 56%, and 97%, respectively. Patients with follicular lymphoma grades 3a and 3b showed 100% 6-year and 10-year overall survival, and progression-free survival did not significantly differ between patients with follicular lymphoma grade 3 and those with follicular lymphoma grades 1 and 2. The absence or presence of Bcl-2 expression and intensity of Bcl-2 expression were not significant prognostic indicators of progression-free survival and overall survival. Likewise, the presence of IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation were not significantly correlated with progression-free survival and overall survival. Follicular lymphoma grade 3 was correlated with nodal disease and negative or lower intensity of Bcl-2 expression, but not with age, stage, or IGH/BCL2 status. In the prerituximab era, grade 3 disease was reported to be associated with a poor prognosis; however, the opposite was true for patients treated with rituximab-containing therapy, regardless of their age or disease stage. Bcl-2 expression and marginal zone differentiation were not prognostic indicators in follicular lymphoma patients treated with rituximab-containing therapy.
Author(s): Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, et al.
Author(s): Teras LR, DeSantis EC, Cerhan JR, Morton LM, Flowers CR, et al.
Author(s): Bierman PJ
Author(s): Bosga-Bouwer AG, Den Berg AV, Haralambieva E, De Jong D, Boonstra R, et al.
Author(s): Horn H, Schmelter C, Leich E, Salaverria I, Katzenberger T, et al.
Author(s): Borovecki A, Korac P, Nola M, Dominis M
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Author(s): Pandolfi A, Barreyro L, Steid U
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Author(s): Lunning M
Author(s): Federico M, Bellei M, Marcheselli L, Luminari S, Lopez-Guillermo A, et al.
Author(s): Strati P, Fowler N, Pina-Oviedo S, Medeiros LJ, Overman MJ, et al.