Author(s): Mathew R, Karantza-Wadsworth V, White E
Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative energy source during periods of metabolic stress to maintain homeostasis and viability. In tumour cells with defects in apoptosis, autophagy allows prolonged survival. Paradoxically, autophagy defects are associated with increased tumorigenesis, but the mechanism behind this has not been determined. Recent evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17972889
Author(s): Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, et al.
Author(s): Yue Z, Jin S, Yang C, Levine AJ, Heintz N
Author(s): Edinger AL, Thompson CB
Author(s): Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, et al.
Author(s): Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, et al.
Author(s): Shen Y, Li DD, Wang LL, Deng R, Zhu XF
Author(s): Miracco C, Cosci E, Oliveri G, Luzi P, Pacenti L, et al.
Author(s): Daniel F, Legrand A, Pessayre D, Borrega-Pires F, Mbida L, et al.
Author(s): Koneri K, Goi T, Hirono Y, Katayama K, Yamaguchi A
Author(s): Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA
Author(s): Bellodi C, Lidonnici MR, Hamilton A
Author(s): Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, et al.
Author(s): Chen S, Rehman SK, Zhang W, Wen A, Yao L, et al.
Author(s): Moretti L, Attia A, Kim KW, Lu B
Author(s): Akar U, Ozpolat B, Mehta K, Fok J, Kondo Y, et al.
Author(s): Xue L, Fletcher GC, Tolkovsky AM
Author(s): Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, et al.
Author(s): Spindler SR1
Author(s): Bergamini E,Cavallini G, Donati A, Gori Z
Author(s): Hanahan D, Weinberg RA
Author(s): Kumar S, Guru SK, Pathania AS, Kumar A, Bhushan S, et al.
Author(s): Bardeesy N, DePinho RA
Author(s): Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, et al.
Author(s): Devarajan E, Chen J, Multani AS, Pathak S, Sahin AA, et al.
Author(s): Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, et al.
Author(s): Zhuang W, Qin Z, Liang Z
Author(s): Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B
Author(s): Verma A, Wang H, Manavathi B, Fok JY, Mann AP, et al.
Author(s): Akar U, Chaves-Reyez A, Barria M, Tari A, Sanguino A, et al.