Author(s): Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, et al.
As part of a randomized placebo-controlled study to evaluate the effect of lycopene supplementation on DNA damage in men with prostate cancer, a nonrandomized 5th arm using tomato sauce was included and reported here. Thirty-two patients with localized prostate adenocarcinoma consumed tomato sauce-based pasta dishes for 3 weeks (30 mg of lycopene/day) before their scheduled radical prostatectomy. Prostate tissue was obtained as biopsies at baseline and as resected tissue at the time of the prostatectomy. Serum and prostate lycopene, serum prostate specific antigen (PSA) concentrations, and leukocyte DNA 8-OH-deoxyguanosine/deoxyguanosine (8OHdG) were measured at baseline and at the end of the intervention. Cancer cells in paraffin sections of prostate biopsies and postintervention resected tissue were compared for 8OHdG staining and for apoptosis. Adherence to the daily consumption of tomato-based entrees was 81.6% of the intended dose, and serum and prostate lycopene concentrations increased 1.97- and 2.92-fold (P < 0.001), respectively. Mean serum PSA concentrations decreased by 17.5% (P < 0.002) and leukocyte 8OHdG decreased by 21.3% (P < 0.005) after tomato sauce consumption. Resected tissues from tomato sauce-supplemented patients had 28.3% lower prostate 8OHdG compared with the nonstudy control group (P < 0.03). Cancer cell 8OHdG staining of Gleason Score-matched resected prostate sections was reduced by 40.5% in mean nuclear density (P < 0.005) and by 36.4% in mean area (P < 0.018) compared with the presupplementation biopsy. Apoptotic index was higher in hyperplastic and neoplastic cells in the resected tissue after supplementation. These data taken as a whole indicate significant uptake of lycopene into prostate tissue and a reduction in DNA damage in both leukocyte and prostate tissue. Whether reduction in DNA damage to prostate cancer cells is beneficial awaits further research, although reduction in serum PSA concentrations is promising.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12424330
Author(s): Giovannucci E
Author(s): Giovannucci E
Author(s): Le Marchand L,Hankin JH, Kolonel LN, Wilkens LR
Author(s): Stacewicz-Sapuntzakis M, Bowen PE
Author(s): Mohanty NK,Saxena S, Singh UP, Goyal NK, Arora RP
Author(s): Van Poppel H,Tombal B
Author(s): Madersbacher S, Berger I, Ponholzer A, Marszalek M
Author(s): Azimi H
Author(s): Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, et al.
Author(s): Obermüller-Jevic UC,Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, et al.
Author(s): Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, et al.
Author(s): Schwarz S,Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, et al.
Author(s): Dewell A, Weidner G, Sumner MD, Chi CS, Ornish D
Author(s): Park E,Stacewicz-Sapuntzakis M, Sharifi R, Wu Z, Freeman VL, et al.
Author(s): Parsons JK, Newman VA, Mohler JL, Pierce JP, Flatt S, et al.
Author(s): Carmody JF,Olendzki BC, Merriam PA, Liu Q, Qiao Y, et al.
Author(s): vanBreemen RB,Sharifi R, Viana M, Pajkovic N, Zhu D, et al.
Author(s): Barber NJ, Barber J
Author(s): Hadley CW, Miller EC, Schwartz SJ, Clinton SK
Author(s): Richelle M,Bortlik K, Liardet S, Hager C, Lambelet P, et al.
Author(s): Burri BJ, Chapman MH, Neidlinger TR, Seo JS, Ishida BK
Author(s): Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, et al.
Author(s): Canene-Adams K,Lindshield BL, Wang S, Jeffery EH, Clinton SK, et al.
Author(s): Limpens J,Schröder FH, de Ridder CM, Bolder CA, Wildhagen MF, et al.
Author(s): Yang CM
Author(s): Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, et al.
Author(s): Venkateswaran V,Fleshner NE, Sugar LM, Klotz LH
Author(s): Mucci LA,Tamimi R, Lagiou P, Trichopoulou A, Benetou V, et al.
Author(s): Liu X
Author(s): Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, et al.
Author(s): Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, et al.
Author(s): Talvas J,Caris-Veyrat C, Guy L, Rambeau M, Lyan B, et al.
Author(s): Qiu X, Yuan Y, Vaishnav A, Tessel MA, Nonn L, et al.
Author(s): SoaresNda C,Teodoro AJ, Oliveira FL, Santos CA, Takiya CM, et al.
Author(s): Teodoro AJ, Oliveira FL, Martins NB, Maia Gde A, Martucci RB, et al.
Author(s): Oborna I
Author(s): Kirsh VA,Mayne ST, Peters U, Chatterjee N, Leitzmann MF, et al.
Author(s): Peters U
Author(s): Kristal AR, Till C, Platz EA, Song X, King IB, et al.
Author(s): Ilic D, Forbes KM, Hassed C
Author(s): Bunker CH, McDonald AC, Evans RW, de la Rosa N, Boumosleh JM, et al.
Author(s): Schröder FH,Roobol MJ, Boevé ER, de Mutsert R, Zuijdgeest-van Leeuwen SD, et al.
Author(s): Barber NJ
Author(s): Edinger MS, Koff WJ
Author(s): Morgia G, Russo GI, Voce S, Palmieri F, Gentile M, et al.
Author(s): Morgia G
Author(s): Morgia G,Mucciardi G, Galì A, Madonia M, Marchese F, et al.
Author(s): Blume-Peytavi U