Drug penetration as studied by noninvasive methods: fourier transform infrared-attenuated total reflection, fourier transform infrared, and ultraviolet photoacoustic spectroscopy

Author(s): Hanh BD, Neubert RH, Wartewig S, Christ A, Hentzsch C

Abstract

The penetration of the drugs dithranol and methoxsalen from semisolid Vaseline formulation into an artificial dodecanol-collodion membrane was followed by three spectroscopic methods; they are, step-scan Fourier transform infrared (FTIR) photoacoustic spectroscopy (PAS) with phase modulation, FTIR-attenuated total reflection (FTIR-ATR), and ultraviolet (UV) PAS. The uptake of the drug in the membrane was quantified by monitoring the dependence of an appropriate drug band on the penetration time. The PAS experiments were carried out with various modulation frequencies for generating various sampling depths. Based on Fick's second law, the diffusion coefficient was derived by numerical fitting of the experimental data. It appears that the diffusion coefficient for the drug in the membrane depends on the distance. The comparative studies demonstrate that FTIR-ATR is favored for permeation studies, whereas the PAS techniques are capable of providing the drug penetration profile in the membrane. Thus, extended experimental data are available for new insight into the penetration process. However, because of the photacoustic cells at hand, PAS is only suitable for in vitro studies.

Similar Articles

Connection between the vibrational dynamics and the cross-linking properties in cyclodextrins-based polymers

Author(s): Crupi V, Fontana A, Giarola M, Majolino D, Mariotto G, et al.

Cyclodextrin-based nanosponges as drug carriers

Author(s): Trotta F, Zanetti M, Cavalli R

Nanosponge formulations as oxygen delivery systems

Author(s): Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, et al.

Cyclodextrin-based nanosponges: a propitious platform for enhancing drug delivery

Author(s): Chilajwar SV, Pednekar PP, Jadhav KR, Gupta GJ, Kadam VJ

Cyclodextrin-based nanogels for pharmaceutical and biomedical applications

Author(s): Moya-Ortega MD, Alvarez-Lorenzo C, Concheiro A, Loftsson T

Tamoxifen citrate loaded amphiphilic beta-cyclodextrin nanoparticles: in vitro characterization and cytotoxicity

Author(s): Memisoglu-Bilensoy E, Vural I, Bochot A, Renoir J M, Duchene D, Hincal A A

The application of nanosponges to cancer drug delivery

Author(s): Trotta F, Dianzani C, Caldera F, Mognetti B, Cavalli R

Phase-controlled supramolecularphoto chirogenesis in cyclodextrinnanosponges

Author(s): Liang W, Yang C, Zhou D, Haneoka H, Nishijima M, et al.

Regenerative medicine and stem cell based drug discovery

Author(s): Sakurada K, McDonald FM, Shimada F

Hydrogels in regenerative medicine

Author(s): Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, Peppas NA

Hydrogel-based drug delivery systems: comparison of drug diffusivity and release kinetics

Author(s): Brandl F, Kastner F, Gschwind RM, Blunk T, Tessmar J, et al.

Controlled drug delivery in tissue engineering

Author(s): Biondi M, Ungaro F, Quaglia F, Netti PA

Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks

Author(s): Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, et al.

Hydrogen-bond dynamics of water confined in cyclodextrinnanosponges hydrogel

Author(s): Crupi V, Fontana A, Majolino D, Mele A, Melone L, et al.

Collective nature of the boson peak and universal transboson dynamics of glasses

Author(s): Chumakov AI, Sergueev I, van B├╝rck U, Schirmacher W, Asthalter T, et al.

Designing materials for biology and medicine

Author(s): Langer R, Tirrell DA

Photodegradable hydrogels for dynamic tuning of physical and chemical properties

Author(s): Kloxin AM, Kasko AM, Salinas CN, Anseth KS

Anomalous diffusion of Ibuprofen in cyclodextrinnanosponge hydrogels: an HRMAS NMR study

Author(s): Ferro M, Castiglione F, Punta C, Melone L, Panzeri W2, et al.