Venous thromboembolism in Jamaican women: experience in a university hospital in Kingston

Author(s): Fletcher HM, Wharfe G, Williams NP, Pedican M, Brooks A, et al.


Objective: To review cases of venous thromboembolism (VTE) at UHWI from 1999-2004, to identify methods of diagnosis, risk factors and to evaluate differences between survivors and fatalities.

Methods: Patients coded with the diagnosis of thromboembolism at the University Hospital of the West Indies (UHWI) from 1999-2004 were identified. The medical records were reviewed to determine the prevalence of thromboembolism and possible variables associated with this diagnosis. In addition, variables associated with fatality were examined by evaluating cases diagnosed at autopsy

Results: There were 959 patients coded for thromboembolism between 1999-2004 at UHWI. Of these, 657 (68.5%) were females and 302 were males (31.5%). During that period, 65,657 women and 40,826 men were admitted to hospital with prevalence rates for thromboembolism of 1% in women and 0.7% in men. Of the 657 females, 520 case notes were located (case identification 80%). Of this, 435 were analysed as confirmed thromboembolism. The median age was 51 years with a range of 2-95 years. Common associations were obesity, 53.5%; age over 50 years, 52.5%; hypertension, 44.7%; immobilisation, 36.3%; cardiac disease, 26%; diabetes, 19.4%; fibroids, 16.3%; surgery, 15.8% and cancer 14%. Recurrent venous thromboembolism occurred in 12.8% and 15.8 % of women (66) died, diagnosed with PE at post-mortem. Using logistic regression analysis, leading risk factors in fatalities compared to survivors were hypertension and increased age. Obesity and surgery were significantly more likely in survivors.

Conclusion: Venous thromboembolism was common in this cohort of women and avoidance of risk factors and institution of prophylaxis in high risk women is important to decrease morbidity and mortality.

Similar Articles

A prospective study of the incidence of deep-vein thrombosis within a defined urban population

Author(s): Nordström M, Lindblad B, Bergqvist D, Kjellström T

A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism

Author(s): Anderson FA Jr, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, et al.

Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study

Author(s): Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, et al.

Age, an independent risk factor for thrombosis

Author(s): MahéI, Caulin C, Bergmann JF

Immobilization and the risk of venous thromboembolism

Author(s): Pottier P, Hardouin JB, Lejeune S, Jolliet P, Gillet B, et al.

Management of pulmonary embolism in a cardiology department

Author(s): OuldzeinH, Nourredine A, Cherradi R, Rahal N, Mechmeche R, et al.

Prolonged work- and computer-related seated immobility and risk of venous thromboembolism

Author(s): Healy B, Levin E, Perrin K, Weatherall M, Beasley R

A prospective study of risk factors for pulmonary embolism in women

Author(s): Goldhaber SZ, Grodstein F, Stampfer MJ, Manson JE, Colditz GA, et al.

Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy

Author(s): Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, et al.

Epidemiology of acute deep vein thrombosis

Author(s): BulgerCM, Jacobs C, Patel NH

Hormonal contraception and risk of venous thromboembolism: national follow-up study

Author(s): Lidegaard Ø, Løkkegaard E, Svendsen AL, Agger C

Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study

Author(s): Rosing J, Middeldorp S, Curvers J, Christella M, Thomassen LG, et al.

Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study

Author(s): Middeldorp S, Meijers JC, van den Ende AE, van Enk A, Bouma BN, et al.

Impact of progestagens on activated protein C (APC) resistance among users of oral contraceptives

Author(s): Alhenc-Gelas M, Plu-Bureau G, Guillonneau S, Kirzin JM, Aiach M, et al.

Effect of four different oral contraceptives on various sex hormones and serum-binding globulins

Author(s): Wiegratz I, Kutschera E, Lee JH, Moore C, Mellinger U, et al.

[Upper limb deep venous thrombosis]

Author(s): Benhamou Y, Marie I, David N, Gbaguidi X, Cailleux N, et al.

Old and new risk factors for upper extremity deep venous thrombosis

Author(s): Blom JW, Doggen CJ, Osanto S, Rosendaal FR

Homocysteine and vascular disease

Author(s): Hankey GJ, Eikelboom JW

The long-term clinical course of acute deep venous thrombosis

Author(s): Prandoni P, Lensing AW, CogoA, Cuppini S, Villalta S, et al.

The duration of oral anticoagulant therapy after a second episode of venous thromboembolism

Author(s): Schulman S, Granqvist S, Holmström M, Carlsson A, Lindmarker P, et al.