Sensitization profiles of Malaysian and Singaporean subjects to allergens from Dermatophagoidespteronyssinus and Blomiatropicalis

Author(s): Yeoh SM, Kuo IC, Wang DY, Liam CK, Sam CK, De Bruyne JA, et al

Abstract

Background:The house dust mites Dermatophagoides pteronyssinus (Der p) and Blomia tropicalis (Blo t) are the most common house dust mite species in Southeast Asia. To date, there have only been a few studies on the sensitization profile of the general populations in Southeast Asia to house dust mites. The aim of this study was to determine the profiles of Der p and Blo t sensitization among Singaporean and Malaysian subjects.

Methods:Enzyme-linked immunosorbent assay was used to detect specific IgE to Der p and Blo t mite crude extracts as well as purified Der p 1, Der p 2 and Blo t 5 allergens. Sera used were from 229 Singaporean subjects (124 with rhinitis, 105 without rhinitis) and 143 Malaysian subjects (94 adults and 49 children with asthma).

Results:The sensitization profile of rhinitis subjects to the dust mite allergens used in this study was as follows: Blo t extract positive: 91/124 (73%); Blo t 5 positive: 62/124 (50%); Der p extract positive: 61/124 (49%); Der p 1 positive: 53/124 (43%); Der p 2 positive: 45/124 (36%). The nonrhinitis subjects' sensitization profile was as follows: Blo t extract positive: 60/105 (57%); Blo t 5 positive: 24/105 (23%); Der p extract positive: 38/105 (36%); Der p 1 positive: 14/105 (13%); Der p 2 positive: 17/105 (16%). The study of Malaysian asthmatic adults showed that 39% of them were sensitized to Der p 1, 32% to Der p 2 and 37% to Blo t 5. Among the asthmatic children, sensitization to Blo t 5, Der p 1 and Der p 2 was 90, 57 and 39%, respectively.

Conclusion:This study clearly revealed that dual sensitization to B. tropicalis and D. pteronyssinus is common in the general populations of Singapore and Malaysia. Sensitization to Blo t 5 is more prevalent than to Der p 1 and Der p 2.

Similar Articles

Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma

Author(s): Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, et al.

A revised nomenclature for allergy

Author(s): Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, et al.

[Time trends and geographical variations in the prevalence of symptoms of allergic rhinitis in 6-7-year-old children from eight areas of Spain according to the ISAAC]

Author(s): Arnedo-Pena A, García-Marcos L, García Hernández G, AguinaguaOntoso I, González Díaz C, et al.

Comparison of skin tests to aeroallergens in Ankara and Seoul

Author(s): Sener O, Kim YK, Ceylan S, Ozanguc N, YooTJ,et al.

Recent invasion of the mountain birch Betulapubescens ssp

Author(s): Truong C, Palmé AE, Felber F

Production of allergenic pollen by ragweed (Ambrosia artemisiifolia L

Author(s): Wayne P, Foster S, Connolly J, Bazzaz F, Epstein P

Heat requirement for the onset of the Oleaeuropaea L

Author(s): Galán C, García-Mozo H, Vázquez L, Ruiz L, de la Guardia CD, et al.

Cities as harbingers of climate change: common ragweed, urbanization, and public health

Author(s): Ziska LH, Gebhard DE, Frenz DA, Faulkner S, Singer BD, et al.

Bronchial hyper-responsiveness and atopy in urban, peri-urban and rural South African children

Author(s): Steinman HA, Donson H, Kawalski M, Toerien A, Potter PC

Continued increase in the prevalence of asthma and atopy

Author(s): Downs SH, Marks GB, Sporik R, Belosouva EG, Car NG, et al.

Allergy practice worldwide: a report by the World Allergy Organization Specialty and Training Council

Author(s): Warner JO, Kaliner MA, Crisci CD, Del Giacco S, Frew AJ, et al.

Continued increase in the prevalence of asthma and atopy

Author(s): Downs SH, Marks GB, Sporik R, Belosouva EG, Car NG, et al.

The work impact of asthma and rhinitis: findings from a population-based survey

Author(s): Blanc PD, Trupin L, Eisner M, Earnest G, Katz PP, et al.

The natural history of peanut allergy

Author(s): Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, et al.

Aeroallergen sensitivity of Thai patients with allergic rhinitis

Author(s): Pumhirun P, Towiwat P, Mahakit P

House dust mite allergen in US beds: results from the First National Survey of Lead and Allergens in Housing

Author(s): Arbes SJ Jr, Cohn RD, Yin M, Muilenberg ML, Burge HA, et al.

Prevalence of indoor allergen exposures among New Orleans children with asthma

Author(s): Rabito FA, Iqbal S, Holt E, Grimsley LF, Islam TM, et al.

House dust mite and cat allergen in different indoor environments

Author(s): Custovic A, Taggart SC, Woodcock A

Longitudinal variability of skin prick test results

Author(s): Kuehr J, Karmaus W, Frischer T, Hendel-Kramer A, Weiss K, et al.