Recommended Conferences

Genetic Engineering and Gene Therapy

Paris, France

Human Genetics and Genetic Disorders

Miami, USA

Tissue Engineering and Regenerative Medicine

Chicago, USA
Related Subjects
 

Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists

Author(s): Huang da W, Sherman BT, Lempicki RA

Abstract

Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging and daunting task. The gene-annotation enrichment analysis is a promising high-throughput strategy that increases the likelihood for investigators to identify biological processes most pertinent to their study. Approximately 68 bioinformatics enrichment tools that are currently available in the community are collected in this survey. Tools are uniquely categorized into three major classes, according to their underlying enrichment algorithms. The comprehensive collections, unique tool classifications and associated questions/issues will provide a more comprehensive and up-to-date view regarding the advantages, pitfalls and recent trends in a simpler tool-class level rather than by a tool-by-tool approach. Thus, the survey will help tool designers/developers and experienced end users understand the underlying algorithms and pertinent details of particular tool categories/tools, enabling them to make the best choices for their particular research interests.

Similar Articles

Rat hippocampal neurons in dispersed cell culture

Author(s): Banker GA, Cowan WM

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

Author(s): Lobsiger CS, Boillee S, Pozniak C, Khan AM, McAlonis-Downes M, et al.

A dramatic increase of C1q protein in the CNS during normal aging

Author(s): Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, et al.

When, where, and how much? Expression of the Kv3

Author(s): Gan L, Kaczmarek LK

Kv3

Author(s): Yasuda T, Cuny H, Adams DJ

A-type K+ channels encoded by Kv4

Author(s): Carrasquillo Y, Burkhalter A, Nerbonne JM

Functional specialization of the axon initial segment by isoform-specific sodium channel targeting

Author(s): Boiko T, van Wart A, Caldwell JH, Levinson SR, Trimmer JS, et al.

Role of axonal NaV1

Author(s): Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, et al.

The role of the Rho GTPases in neuronal development

Author(s): GovekEE, Newey SE, van Aelst L

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

Author(s): Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, et al.

Potential role of culture mediums for successful isolation and neuronal differentiation of amniotic fluid stem cells

Author(s): Orciani M, Emanuelli M, Martino C, Pugnaloni A, Tranquilli AL, et al.