Author(s): Lezon-Geyda K,Najfeld V, Johnson EM
Deletions or monosomy of chromosomes 5 and 7 are frequently observed in myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). In this study two genes, PURA and PURB, encoding functionally cooperative proteins in the Pur family, are localized to chromosome bands 5q31.1 and 7p13, respectively. One or both of these loci are shown to be hemizygously deleted in 60 MDS or AML patients using fluorescence in situ hybridization (FISH). High-resolution mapping of PURA localizes it approximately 1.1 Mb telomeric to the EGR-1 gene. Frequency of PURA deletion and segregation with EGR-1 indicate that PURA is within the most commonly deleted segment in myeloid disorders characterized by del(5)(q31). No mutations have been detected within the coding sequence of PURA. Concurrent deletions of PURA and PURB occur in MDS at a rate nearly 1.5-fold higher than statistically expected and in AML at a rate > 5-fold higher. This novel simultaneous deletion of two closely related gene family members may thus have consequences related to progression to AML. Pur alpha, an Rb-binding protein, has been implicated in cell cycle control and differentiation, and Pur alpha and Pur beta are reported to function as heterodimers. Alterations in these genes could affect a delicate balance critical in myeloid development.
Referred From: https://pubmed.ncbi.nlm.nih.gov/11417483/
Author(s): Ghafouri-Fard S,Nekoohesh L, Motevaseli E
Author(s): Ploeg M,Aben KK, Kiemeney LA
Author(s): Cheung G,Sahai A, Billia M, Dasgupta P, Khan MS
Author(s): Biagioli MC, Fernandez DC, Spiess PE, Wilder RB
Author(s): Zhu XL, Ai ZH, Wang J, Xu YL, Teng YC
Author(s): Wang HF, Wang JS
Author(s): Schiffer E,Vlahou A, Petrolekas A, Stravodimos K, Tauber R, et al.
Author(s): Chin L, Hahn WC, Getz G, Meyerson M
Author(s): Horvath S, Dong J
Author(s): Langfelder P, Horvath S
Author(s): Kristensen VN,Lingjærde OC,Russnes HG,Vollan HK,Frigessi A, et al.
Author(s): Stranger BE, Stahl EA, Raj T
Author(s): Gautier L, Cope L, Bolstad BM, Irizarry RA
Author(s): Smyth, GK
Author(s): Song L, Langfelder P, Horvath S
Author(s): Zhang W, Zang Z, Song Y, Yang H, Yin Q
Author(s): Mason MJ, Fan G, Plath K, Zhou Q, Horvath S
Author(s): Zhang B, Horvath S
Author(s): Yip AM, Horvath S
Author(s): Li L, Shiga M, Ching WK, Mamitsuka H
Author(s): Xiao X, Moreno-Moral A, Rotival M, Bottolo L, Petretto E
Author(s): Puniya BL, Kulshreshtha D, Verma SP, Kumar S, Ramachandran S
Author(s): Frantzi M,Makridakis M, Vlahou A
Author(s): Zeng T, Sun SY, Wang Y, Zhu H, Chen L
Author(s): Liu R, Wang X, Aihara K, Chen L
Author(s): He D, Liu ZP, Honda M, Kaneko S, Chen L
Author(s): De Giorgi V, Monaco A, Worchech A, Tornesello M, Izzo F, et al.
Author(s): Gout S,Brambilla E, Boudria A, Drissi R, Lantuejoul S, et al.
Author(s): An Y, Zhou Y, Ren G, Tian Q, Lu Y, et al.
Author(s): Belkina AC, Blanton WP, Nikolajczyk BS, Denis GV
Author(s): Wyce A,Degenhardt Y, Bai Y, Le B, Korenchuk S, et al.
Author(s): Chan WK,Bhalla AD, Le Hir H, Nguyen LS, Huang L, et al.
Author(s): Karam R,Carvalho J, Bruno I, Graziadio C, Senz J, et al.
Author(s): Wang J,Peng X, Peng W, Wu FX
Author(s): Ghosh M,Brancato SJ, Agarwal PK, Apolo AB
Author(s): Arum CJ,Anderssen E, Tømmerås K, Lundgren S, Chen D, et al.
Author(s): Oppezzo P,Dighiero G
Author(s): Boulalas I,Zaravinos A, Karyotis I, Delakas D, Spandidos DA
Author(s): Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, et al.
Author(s): Fernández-Medarde A, Santos E