Demonstration of novel innate immune cells in psoriasis

Psoriasis is a common chronic inflammatory skin disorder affecting ~2% of the population worldwide. Both the adaptive and innate immune systems are important in driving the inflammation in genetically susceptible individuals. HLA-Cw6 located within the PSORS1 region on chromosome 6 is the most important psoriasis genetic marker. Correlations of HLA-C expression with different disease incidence and progression are described in the context of HLA-C’s interaction with killer-like immunoglobulin receptors (KIR) expressed on innate immune effector cells; natural killer (NK) and natural killer T (NKT) cells.