Author(s): HelliwellSolà J, Clayden MJ
The structural influence of a single Gly residue inserted into an Aib(16) homooligomer was studied in the solid state by X-ray crystallography. The peptides N(3)Aib(8)GlyAib(8)PheNH(2) (1) and CbzPheAib(8)GlyAib(8) (2) were found to adopt well-defined helical structures, which are broadly 3(10) helical. Indeed, 2 is the longest crystallographic 3(10) helix thus far reported. However, in the region of the central Gly residue, a loosening of the 3(10) structure is observed in both peptides, with 1 clearly showing local adoption of an α-helical structure in the region of residues 7-9.
Referred From: https://pubmed.ncbi.nlm.nih.gov/20725951/
Author(s): Aravinda S,Shamala N,Karle IL, Balaram P
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