Author(s): Gurdon JB, Wilmut I
We review experiments in which somatic cell nuclei are transplanted singly to enucleated eggs (metaphase II) in amphibia and mammals and as multiple nuclei to the germinal vesicle of amphibian oocytes (prophase I). These experiments have shown the totipotency of some somatic cell nuclei, as well as switches in cell type and changes in gene expression. Abnormalities of nuclear transplant embryo development increase greatly as nuclei are taken from progressively more differentiated donor cells. The molecular changes that accompany the reprogramming of transplanted nuclei help to indicate the mechanisms used by eggs and oocytes to reprogram gene expression. We discuss the importance of chromosomal protein exchange, of transcription factor supply, and of chromatin access in reprogramming.
Referred From: https://pubmed.ncbi.nlm.nih.gov/21555407/
Author(s): Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrers G, et al.
Author(s): Nichols J, Smith A
Author(s): Gangaraju VK, Lin H
Author(s): Yamanaka S, Blau HM
Author(s): Takahashi K, Yamanaka S
Author(s): Stadtfeld M, Maherali N, Breault DT, Hochedlinger K
Author(s): Chan EM, Ratanasirintrawoot S, Park IH, Manos PD, Loh YH, et al.
Author(s): Payer B, Lee JT, Namekawa SH
Author(s): Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, et al.
Author(s): Kim K, Doi A, Wen B, Ng K, Zhao R, et al.
Author(s): Hu Q, Friedrich AM, Johnson LV, Clegg DO
Author(s): BarNur O, Russ HA, Efrat S, Benvenisty N
Author(s): Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, et al.
Author(s): Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, et al.
Author(s): Kim K, Zhao R, Doi A, Ng K, Unternaehrer J, et al.
Author(s): Zhao T, Zhang ZN, Rong Z, Xu Y
Author(s): Awe JP, Byrne JA
Author(s): Xu F, Flowers S, Moran E
Author(s): Houlard M, Berlivet S, Probst AV, Quivy JP, Héry P, et al.
Author(s): Pivot-Pajot C, Caron C, Govin J, Vion A, Rousseaux S, et al.
Author(s): Kim SK, Suh MR, Yoon HS, Lee JB, Oh SK, et al.
Author(s): Liu YJ, Nakamura T, Nakano T
Author(s): Jude CD, Climer L, Xu D, Artinger E, Fisher JK, et al.
Author(s): Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, et al.
Author(s): Becker M, Becker A, Miyara F, Han Z, KiharaM,et al.
Author(s): Aoto T, Saitoh N, Sakamoto Y, Watanabe S, Nakao M
Author(s): Lee G, Papapetrou EP, Kim H, Chambers SM, Tomishima MJ, et al.
Author(s): Moretti A, Bellin M, Welling A, Jung CB, Lam JT, et al.
Author(s): Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, et al.