Author(s): Krueger JG
Psoriasis vulgaris is the most prevalent T-cell-mediated inflammatory disease in humans. The pathogenesis of psoriasis is linked to activation of several types of leukocytes that control cellular immunity and to a T-cell-dependent inflammatory process in skin that accelerates the growth of epidermal and vascular cells in psoriasis lesions. Critical steps in immunologic activation include Langerhans cell maturation (activation), T-cell activation, differentiation and expansion of type 1 T cells, selective trafficking of activated T cells to skin, and induction of an inflammatory cytokine and chemokine cascade in skin lesions. In turn, each of these steps offers an opportunity for intervention with engineered biologic therapeutics.
Referred From: https://pubmed.ncbi.nlm.nih.gov/11756941/
Author(s): Ameglio F, Bonifati C, Fazio M, Mussi A, Trento E, et al.
Author(s): Krueger J, Bowcock A
Author(s): Mehlis SL, Gordon KB
Author(s): Bos JD, de Rie MA, Teunissen MB, Piskin G
Author(s): Lowes MA, Bowcock AM, Krueger JG
Author(s): Prens EP, Benne K, van DJ, Bakkus M, Brakel K, et al.
Author(s): Mangalam AK, Veena T, David CS
Author(s): Johnson DR
Author(s): Arican O, Aral M, Sasmaz S, Ciragil P
Author(s): Jacob SE, Nassiri M, Kerdel FA, Vincek V
Author(s): Pietrzak A, Kozioł-Montewka M, Lecewicz-Toruń B, Krasowska D
Author(s): Szepietowski JC, Bielicka E, Nockowski P, Noworolska A, Wasik F
Author(s): Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM
Author(s): Cesare DC, Meglio PD, Nestle FO
Author(s): Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, et al.
Author(s): Makhatadze NJ
Author(s): Chaudhari U, Romano P, Mulcahy L, Dooley L, B aker D, et al.
Author(s): Mizutani H, Ohmoto Y, Mizutani T, Murata M, Shimizu M
Author(s): Mak R, Hundhausen C, Botti E, Laggner U, Grys K, et al.
Author(s): Murphy M, Philip K, Grant- Kels JM